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7432251 |
Methods of treating neurological diseases by regulating migration of neuroblasts in the adult nervous system with tenascin-R
This invention provides a method for regulating migration of neuronal progenitor cells in the nervous system of a mammal. The method comprises providing a mammal with TNR, a biologically active...
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7432250 |
Oligoribonucleotides and ribonucleases for cleaving RNA
Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2′-pentoribofuranosyl nucleosides that activate dsRNase. The...
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7432249 |
Oligoribonucleotides and ribonucleases for cleaving RNA
Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2′-pentoribofuranosyl nucleosides that activate dsRNase. The...
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7429656 |
Inhibition of SARS-associated coronavirus (SCoV) infection and replication by RNA interference
The present invention relates to therapeutic agents useful for the treatment of Severe Acute Respiratory Syndrome (SARS) in humans. In particular, the present invention relates to RNA interference...
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7427607 |
Drug administration method
A method of administering a drug whereby a fine drug powder can be accurately administered to a target site (in particular, a target site in the body cavity) via fluidization and spraying with a...
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7427605 |
Inhibitors of ribonucleotide reductase subunit 2 and uses thereof
The present application relates to inhibitors of ribonucleotide reductase subunit 2 (R2), and methods and compositions related to the R2 inhibitors. In certain embodiments, the R2 inhibitors...
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7427604 |
DNA encoding an antigenic protein of Eimeria apical membrane antigen 1 and use thereof
This invention provides a novel DNA for preventing avian coccidiosis and use thereof. The novel DNA encodes an antigenic protein of Eimeria apical membrane antigen 1, and is used for DNA vaccine...
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7427602 |
Sustained DNA delivery from structural matrices
Disclosed are particular 3-dimensional structural matrices containing nucleic acids, various fabrication processes and methods for the prolonged release of nucleic acids in various biological...
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7427503 |
Method for transferring material in a cell system
Described is a method for method for transferring material through the membrane of at least one cell, wherein the transfer is carried out in the presence of trehalose. This method is applicable in...
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7427402 |
Method of evaluating inflammatory skin disorders using IL-17 and/or IL-19
Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19,...
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7425545 |
Modulation of C-reactive protein expression
Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive...
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7425544 |
Modulation of eIF4E expression
Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid...
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7425543 |
Microencapsulated materials and method of making same
A method of forming microspheres of a bioactive material, such as a protein polymer or drug by nebulizing a solubilized form of a material to be encapsulated and an encapsulating material, such as...
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7423023 |
Enhancement of immune response using targeting molecules
The present invention provides methods of enhancing the immune response to an immunogen and to compositions for use in these methods. In particular the present invention provides a DNA molecule for...
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7420030 |
Aminopeptidase A (APA) targeting peptides for the treatment of cancer
The present invention concerns compositions and methods for the treatment of cancer. More specifically, the present invention relates to identification of aminopeptidase A (APA) as a functional...
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7419824 |
BASB006 polypeptides from Neisseria meningitidis and immunogenic compositions thereof
The invention provides BASB006 polypeptides and polynucleotides encoding BASB006 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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7416842 |
DNA virus microRNA
The invention relates to isolated nucleic acid molecules comprising the sequence of a DNA virus microRNA. In another embodiment, the invention relates to single stranded DNA virus microRNA...
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7414122 |
Nucleic acids encoding B7-Like molecules and uses thereof
The present invention provides B7-Like (B7-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for...
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7414035 |
hKIS composition and methods of use
Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing...
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7414033 |
Modulation of diacylglycerol acyltransferase 1 expression
Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding...
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7414032 |
Vaccine comprising a polynucleotide encoding an antigen recognized by a CD4+ helper T-cell and a polynucleotide encoding a tumor specific or associated antigen recognized by a CD8+ CTL
The present invention relates to a DNA vaccine for developing tumor-specific immunity. Specifically, the invention relates to a DNA vaccine comprising antigens recognized by CD4 + helper T cells...
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7414020 |
Human checkpoint kinase, hCDS1, compositions and methods
The invention provides for a novel human checkpoint kinase gene, hCDS1, comprising the nucleic acid sequence of residues 66-1694 of SEQ ID NO: 1, a protein expressed from the gene, fragments and...
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7410954 |
Adenovirus serotype 30 (Ad30)
The present invention provides an adenovirus serotype 30 (Ad30) fiber amino acid sequence. The present invention also provides polynucleotides and expression vectors encoding an Ad30 fiber and...
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7410953 |
Anticancer agent
The present invention is to offer a pharmaceutical agent which is capable of suppressing the growth of cancer in cancer cells and the surrounding tissues thereof or in tissue of non-diseased part....
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7410644 |
Recombinant pox virus for immunization against tumor-associated antigens
Recombinant pox viruses capable of expressing cell-encoded, tumor-associated antigens are disclosed. The recombinant viruses are useful for evoking an immune response against the antigen.
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7408053 |
Recombinant DNA constructs for GAG polypeptides and polypeptides produced thereby
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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7407944 |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods...
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7407943 |
Antisense modulation of apolipoprotein B expression
Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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7407801 |
Truncated CMV promoters and vectors containing same
The present invention relates to nucleic acid molecules comprising certain truncated forms of the human cytomegalovirus (CMV) immediate-early enhancer-promoter, either alone or operably linked to...
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7407661 |
Methods and reagents that generate a CD8 T cell immune response
New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes...
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7405292 |
Cellular genes regulated by HIV-1 infection and methods of use thereof
This invention provides cellular gene products which have anti-apoptotic activity in HIV-1 infected cells and provides agents for the inhibition of the cellular gene products.
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7405205 |
Antitumor antisense sequences directed against R1 and R2 components of ribonucleotide reductase
Compounds and methods for modulating cell proliferation, preferably inhibiting the proliferation of tumor cells are described. Compounds that may be used to modulate cell proliferation include...
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7404950 |
Induced activation in dendritic cell
The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions...
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7402574 |
Antisense composition and method for treating cancer
A method and composition for treating colorectal cancer is disclosed. The method involves administering to a subject, a therapeutically effective amount of a morpholino antisense compound (i)...
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7402573 |
Use of nanoparticles for the DNA administration to a target organ
The invention relates to the use of DNA-loaded nanoparticles for a transfection of DNA into cells in vitro or in vivo.
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7402572 |
Immunostimulatory nucleic acid molecules
Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a...
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7402571 |
Methods and pharmaceutical compositions for healing wounds
A pharmaceutical composition and method for inducing or accelerating a healing process of a skin wound are described. The pharmaceutical composition contains, as an active ingredient, a...
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7402570 |
Amplification of human MDM2 gene in human tumors
A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting...
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7402434 |
Splice choice antagonists as therapeutic agents
The invention relates to methods and reagents for influencing alternative RNA splicing in living cells. More particularly, the invention relates to novel means for influencing RNA splice choice in...
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7399753 |
Trans-splicing mediated photodynamic therapy
The present invention provides methods and compositions for conferring selective death on cells expressing a specific target precursor messenger RNA (selective target pre-mRNA). The compositions of...
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7399752 |
High affinity nucleic acid ligands to lectins
This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin, E-selectin...
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7399751 |
Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
The present invention provides a method of providing an individual with a biological factor or intermediate thereof which comprises introducing into the individual Sertoli cells genetically altered...
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7399750 |
Methods for cardiac gene transfer
Methods for the delivery of genes to improve cardiac function including the use of viral vectors, isolation of the heart from systemic circulation, and induction of hypothermia/cardiac arrest are...
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7396922 |
Regulation of hypoxia-inducible gene expression with antisense Inhibitory PAS domain protein
A pharmaceutical composition comprises the sequence of SEQ ID NO:s 3-5 or pharmaceutically equivalent sequences. Methods employing the pharmaceutical compositions include treatments to increase...
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7396824 |
2-O sulfatase nucleic acid compositions
The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode...
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7396823 |
Therapy inhalation involving antisense oligonucleotides for treating idiopathic pulmonary fibrosis
The invention provides antisense DNA oligonucleotides which are effective in inhibiting the expression of a wild type COL1A1 gene, wherein said oligonucleotides are used in inhalation therapy to...
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7396822 |
Immunogenic minicells and methods of use
The disclosed invention relates to immunogenic minicells cells (anucleated) and their use to induce an immune response from a subject.
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7396821 |
Intravascular delivery of nucleic acid
Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then...
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7396536 |
Parasitic helminth cuticlin proteins and uses thereof
The present invention relates to: parasitic helminth cuticlin proteins; parasitic helminth cuticlin nucleic acid molecules, including those that encode such cuticlin proteins; antibodies raised...
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7396528 |
Corneal cells expressing active agents and methods of use thereof
The invention relates to methods of modifying cells of corneal tissue to express an active agent, to modified corneal tissue, to vectors utilised in such methods and to methods of xeno- and...
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